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In the present study we have explored this approach, in a proof-of-principle study, using silicon dioxide nanoparticles (nano-SiO2). These are relatively easy to prepare and inexpensive to produce and their properties have been found to be particularly suitable for biomedical applications, such as drug delivery and imaging, and for construction. However, it has also been reported that rats exposed to nano-SiO2 by inhalation can develop pulmonary and cardiovascular damage such as pulmonary inflammation, myocardial ischemic damage, atrio-ventricular blockage, and increases in fibrinogen concentration and blood viscosity. The mechanisms by which such damage occurs are unknown. Proteomics has been used in several recent publications to investigate cellular responses to carbon nanotubes. Few other nanomaterials have been studied using proteomics. 

In one study, proteomics was successfully applied to assess the effects of silicon dioxide nanoparticles (nano-SiO2) on skin using a human keratinocytes cell line (HaCaT). Under the conditions used differences in the expression levels of proteins associated with oxidative stress, cytoskeleton, molecular chaperones, energy metabolism, apoptosis and tumor development were found.

In this present study, we chose to investigate the interaction and effects of silicon dioxide nanoparticles (nano-SiO2) on proteins expressed in human lung epithelial cell cultures in an attempt to understand the interactions that occur and the biological consequences of exposure of lung to nanoparticles. The results showed alteration in several pathways of toxicological importance and suggest that the expression levels of the proteins involved may prove useful as indicators of inhalation toxicity. Nano-SiO2 is important inorganic solid materials, for the upgrading of products in many industries, here we introduce the nano-SiO2 general preparation methods, advantages and disadvantages of the various production method are reviewed. Clarify the modification mechanism, citing common modification method, for specific applications briefly summarize, study about nano-SiO2 in various applications demonstrated superior performance and some strange properties.



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