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Researchers from the University of California, USA, recently published a paper in the journal Nanoscale describing a new cup-shaped silicon dioxide nanoparticle similar to exosomes and a significant ultrasound impedance for labeled stem cells in regenerative medical imaging Mismatch phenomenon. These exosomes-like silica nanoparticles (ELS) were synthesized by the reaction of the emulsion template with the silica precursors bis-triethoxysilyl-ethane (BTSE) and bis-3- Bis-3-trimethoxysilyl-propyl-amine (TSPA).

The researchers found that 40% of the TSPA can be exosporin-like morphology, and suitable for labeling positive mesenchymal stem cells. The new structure was then compared to other silicon dioxide structures used in ultrasound, including Stober silica nanoparticles (SSN), MCM-41 mesoporous silica nanoparticles (MCM-41 Mesoporous silica nanoparticles (MSN) and mesocellular foam silicon dioxide nanoparticles (MCF), and then found that ELS could result in an enhanced stem cell signaling response because of the positive charge carried by the cells, which facilitates uptake of cells and echoes .

In vivo assays were performed with less than 500 cells and no cytotoxicity was detected at the concentrations used for labeling. Using this new structure, the researchers hope that the imaging of exosomes-like particles can eventually be used in many applications, including drug delivery.

Ultrasound is a key technology in many areas of medicine, including the emerging applications of obstetrics, oncology and cardiology in regenerative medicine. However, a key limiting factor for ultrasound is the low contrast of the target tissue relative to the background.



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