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Mesoporous silicon dioxide nanoparticles (MSNs) are widely used in food, cosmetics and pharmaceuticals, FDA and WHO are recognized silicon dioxide is a safe additive, approved its widespread use. And because it can prevent all kinds of powder bonded together, MSNs in the application of cosmetics is extremely widespread and popular. Recently, the research team from the first Affiliated Hospital of China Medical University found that MSNs are genotoxic and can cause DNA damage, the research results published in the Journal of Nanoscience and Nanotechnology magazine.

The team established a high-throughput screening technology for nanoparticles in different forms of MSNs, designed a DT40 cell capable of internalizing nanoparticles and defective in multiple DNA repair pathways, and found that both spherical and rod-shaped MSNs are cytotoxic and genetically toxicity, and rod-like MSNs more toxic. In addition, the study also found that MSNs can induce oxidative damage, and lead to a large number of mitotic chromosomal abnormalities.

This is not the first time that nanoparticles used in food, cosmetics and pharmaceuticals have genotoxicity and potentially increase the risk of many cancers, so caution should be exercised when using nanoparticles.



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