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Poor targeting is one of the biggest limitations for nanomaterials for cancer, Chinese Academy of Sciences Institute of Physical and Chemical Technology Controllable Preparation and Application of nanomaterials in the laboratory researcher Fangqiong Tang led in recent years has been committed to the development of new nano-carriers and their biomedical applications. In 2009 they published a new method for the synthesis of mesoporous hollow silicon dioxide having a sandwich structure (Adv. Mater. 2009, 21, 3804-3807), after biomedical applications of silica sandwich made a series of work, Related articles published in Angew Chem. Int. Ed., ACS Nano, on Biomaterials.

Recently, their combined Xuanwu Hospital, Shenzhen Sun Yat-sen Cardiovascular Hospital, Military Medical Sciences, Beijing Huamei a fine nano-materials Technology Co., Ltd. and a number of units, designed a new and efficient tumor targeting policy: drug sandwich silicon dioxide nanoparticles bind to mesenchymal stem cells, mesenchymal stem cells by cytokines secreted by tumor cells attraction can take the initiative to track the tumor cells, the drug-loaded nanoparticles are transported to all parts of the tumor tissue, the release Drug-induced apoptosis of tumor cells. This new method uses targeted chemotactic effect of mesenchymal stem cells as "targeting truck" like "Trojan horse", as collaborated completely kill the tumor cells, as compared to the traditional method of targeting a stronger initiative, targeted and targeted.

This research method is a tumor-targeted nanomedicine has opened up new ideas, and to improve the clinical application of nanomedicine has brought new hope. Reviewers that "they used innovative and interesting nanomaterials, and mesenchymal stem cells combine to make the drug-loaded nanoparticles targeted and efficient like a bullet, kill tumor cells."

In this study, an efficient approach for tumor-targeted drug delivery was developed with mesenchymal stem cells as the targeting vehicle and a silica nanorattle as the drug carrier. A silicon dioxide nanorattle–doxorubicin drug delivery system was efficiently anchored to mesenchymal stem cells (MSCs) by specific antibody–antigen recognitions at the cytomembrane interface without any cell preconditioning. Up to 1500 nanoparticles were uploaded to each MSC cell with high cell viability and tumor-tropic ability. The intracellular retention time of the silica nanorattle was no less than 48 h, which is sufficient for cell-directed tumor-tropic delivery. In vivo experiments proved that the burdened MSCs can track down the U251 glioma tumor cells more efficiently and deliver doxorubicin with wider distribution and longer retention lifetime in tumor tissues compared with free DOX and silicon dioxide nanorattle-encapsulated DOX. The increased and prolonged DOX intratumoral distribution further contributed to significantly enhanced tumor-cell apoptosis. This strategy has potential to be developed as a robust and generalizable method for targeted tumor therapy with high efficiency and low systematic toxicity.



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