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CAS Shanghai Life Science Institute of Nutritional Sciences, Chinese Academy of Sciences in cooperation with the group Songhai Yun Shanghai Institute of Applied Physics Fan Chunhai group, found that silicon dioxide nanoparticles do not produce cytotoxicity in a dose range will induce molecular Dvl Wnt signaling pathway of degradation interference Wnt signal transduction and target gene expression, thus affecting the Wnt signaling pathway mediated by important physiological and pathological processes. Research recently published online in the "therapeutic diagnostics."

Excellent features and new features to make nanomaterials in medicine, food and cosmetics and other fields have broad application prospects. At the same time, the biological effects and biosecurity requires a comprehensive evaluation. Silicon dioxide nanoparticles have good biocompatibility, which is widely used as a biological carrier. Since silica is a common food additive, nanoscale silicon dioxide can be used if the food industry is also cause for concern.

The researchers found that the silicon dioxide nanoparticles interfere with the transfer of Wnt signaling, thereby affecting adipocyte differentiation, cancer cell migration and biological processes in zebrafish embryo development. Silica nanoparticles by way of a signaling similar regulatory factors influence the Wnt signaling pathway, cells within the silicon dioxide nanoparticles can lead to swallow molecule Dvl Wnt signaling pathway and enter the lysosomal degradation pathway and Wnt other signaling molecules and are not affected.

 

 

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