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Malignant serious harm to human health, traditional chemotherapy drugs currently in use have serious side effects, and the emergence of nanotechnology for antineoplastic design provides a new idea. Wherein the mesoporous silicon dioxide nanomaterials because of its safety, low toxicity, has a high specific surface area, larger pore size and pore volume, and surface characteristics of easy modification to the study of nanomaterials as drug delivery systems has been gradually He entered the biomedical field. Professor Chen Feng group filled in recent years has been committed to the functional design of silicon dioxide nano-materials, and as a chemotherapeutic drug delivery system, to explore its potential application mechanism in cancer diagnosis and treatment and effect.

In order to solve the metal complexes in cancer therapy problems faced, Professor Chen team designed and synthesized a kind of targeted RGD peptide-modified silicon dioxide nano-carrier, and as a metal complex delivery system, enhancing drug for cancer selective cells and normal cells, thus greatly improving the antitumor activity of the drug and reduce its toxic side effects. Nano-modified RGD peptide enables the integration of drugs specifically recognize and bind with high expression of tumor cell membrane surface receptors, thereby enhancing drugs through the nano-integrin-mediated cellular uptake of the drug to achieve the targeted tumor cells. In addition, the study found, the potential mechanism of action targeting nano-drugs inhibit tumor cell growth through activation of death receptor pathway inside the cell, and further induce reactive oxygen species accumulate in cells, causing DNA damage, activation of downstream p53, AKT and MAPKs signaling pathway, ultimately induce apoptosis. Based on the above experimental results published (2014,53, 12532) on Professor Chen Tianfeng team in 2014, it has top magazines respectively in the art Advanced Functional Materials (2014,24, 2754) and Angewandte Chemie International Edition, it is worth mentioning that, results of their research is Advanced Functional Materials journal is published as a cover story, Materials Views China website also conducted a special highlight of the report.

Targeting system based on silicon dioxide nanoparticles exhibited by effective anti-tumor activity and low toxicity, Professor Chen Tianfeng team in subsequent research while the cell-penetrating peptide and protein transferrin modified silica nano system, nano improving drug targeting while enhancing its ability to penetrate the cell membrane. And synthesized this versatile nanodrug as a radiotherapy sensitizers to achieve the effect of concurrent chemoradiotherapy. The study was published in the art magazine Zone 1 Biomaterials (2015,51, 30) on 2015. Then, based on the tumor cells and endothelial cells biochemical similarity, designed and synthesized double targeting tumor and vascular cells silica nano system. It found that two-targeted nanomedicine by inhibiting the growth of vascular cells to cut off the tumor cell proliferation required nutrients while directly induce apoptosis of tumor cells, and ultimately achieve the dual inhibition of tumor angiogenesis therapeutic effects of the research published in the same year zone 1 art magazine Journal of Materials Chemistry B (2015,3, 6338).

 

 

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