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Lectin carbohydrate molecules have specific adsorption properties on endotoxin structure polysaccharide components adsorbed, the establishment of a lectin adsorption system to remove the collagen solution toxins. After a silicon dioxide glass by etching, and then to amino silane amination, lectin grafted thereon. The results showed that 1, 2 and 5 g / lectin L for internal collagen solution toxin adsorption rates are greater than 99%; 30 grafted lectin glass beads can be removed 8.4 mL collagen solution (at a concentration of 2 g / L) endotoxin (removal efficiency greater than 99%).

Preferably optimum preparation of porous silicon dioxide microspheres of essential oil from Cinnamon. With porous silica adsorption Cinnamon oil, sodium alginate as matrix materials prepared by dripping volatile oil of cinnamon microspheres; to microsphere size and distribution, drug loading and encapsulation rate as the marker, using L9 (34) orthogonal test preparation process optimization. Scanning electron microscopy (SEM), thermal analysis (TGA) and infrared spectroscopy (IR) and other methods for volatile oil microspheres were characterized and in vitro release test.

Porous silicon dioxide carrier to prepare tanshinone solid dispersion comparative spray drying and on in vitro drug dissolution solvent. Using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X- ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) technology to structural features solid dispersion analysis and study, and study vitro dissolution. The characterization results show two methods of preparing the solid dispersion of the drug are highly dispersed amorphous form.

 

 

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