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Preparation of 5-fluorouracil wrapped silicon dioxide (5-Fu / Si O2) nanoparticles, and study its parameters and pharmaceutics in vitro cytotoxicity. The method of using reverse phase micro-emulsion prepared by 5-Fu / Si O2 nanoparticles synthesis conditions 5-Fu inputs and reaction time were optimized, stability and in vitro study of nanoparticles and their MTT assay In vitro cytotoxicity studies. When the results of 5-Fu inputs to 1.33 mg and the reaction time was 24 h, 5-Fu / drug loading rate and encapsulation efficiency Si O2 highest nm, respectively, 1.03% and 24.77%, while the Nano in 48 h in the release rate of 41.31%, no significant change in the particle size 7 d. Cytotoxicity experiments show, 5-Fu / Si O2 Nano on human hepatoma cell having a significant inhibitory effect, while the smaller nano-Si O2 blank on Cell Activity. Conclusion prepared good stability, long sustained period of 5-Fu / Si O2 nanoparticles for the development of 5-Fu sustained release dosage forms provide a new way of thinking.

Prepare of two phosphorylated modified mesoporous silicon dioxide submicron spherical particles are particles (PMPS-Ⅰ), only the outer surface of the graft phosphate groups inside and outside surfaces of the particles are grafted phosphate groups (PMPS- ⅱ). Particles having a uniform size and arrangement rules hexahedral one-dimensional through channels. Silicon Dioxide particles were prepared and sulfonated polyether ether ketone (SPEEK) solution was prepared by blending hybrid film. Compared with the hybrid PMPS-Ⅰ film fill, fill, PMPS-Ⅱ hybrid membrane exhibits good proton conductivity. When the filling amount PMPS-Ⅱ was 5% (by mass), the hybrid membrane at 60 ℃, 100% relative humidity at the highest proton conductivity of 0.241 S · cm ~ (-1). The results show that, through successive proton transfer channel helps improve hybrid proton conductivity of the membrane.

Improve the surface hydrophilic PET material. Blending method stannous chloride and after PET film formation method by blending graft, graft in the blend membrane surface of amino-modified nano-silica prepared strongly hydrophilic PET material. static contact angle, Fourier transform infrared spectroscopy, atomic force microscopy by means of PET material surface characterization. the results of the amino-modified nano-silica can be successfully grafted stannous blended with PET material surface. when stannous chloride content of 0.3%, the blend film contact angle 98 ° down to 74.5 °. nano-silica solution blend of amino-modified membrane graft at 20 h, PET material surface contact angle 74.5 ° down to 7.8 °, hydrophilic been greatly improved. grafted film was immersed in distilled water for 10 d later, PET material surface contact angle increased from 7.8 ° to 34.9 °. Conclusion stannous chloride and PET material blends, grafted amide-modified nano-silicon dioxide greatly improve the hydrophilic surface of the PET material.


 

 

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