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Prepare Tripterine release solid dispersion, the drug release rate increase, while slow-release drugs to reduce its toxic side effects. Methods: colloidal silicon dioxide as the carrier were prepared by solvent evaporation method tripterine solid dispersions, to study its dissolution and phase characteristics. Results: Tripterine solid dispersion and colloidal silica prepared by 1:12, the drug is released slowly, at 8 h in vitro release rate of the drug more than 90%. By differential scanning calorimetry, X-diffraction and electron microscopy, solid dispersion of the drug in amorphous form present in the vector. Conclusion: Tripterine solid dispersion of colloidal silica prepared by the process system simple, slow release of the drug and the release of more complete and has practical value.

However, exposure to silicon dioxide dust you should be careful, because it may cause lung disease. The Occupational Safety and Health Administration (OSHA) issued a final ruling for exposure to silicon dioxide dust. The standard is an effort to protect workers in construction, general industry and maritime from silicosis, lung cancer, chronic obstructive pulmonary disease and kidney disease. 

Silicosis, an irreversible but preventable disease, is the illness most closely associated with occupational exposure to the material, which also is known as silica dust. Occupational exposures to respirable crystalline silicon dioxide are associated with the development of silicosis, lung cancer, pulmonary tuberculosis, and airways diseases. These exposures may also be related to the development of autoimmune disorders, chronic renal disease, and other adverse health effects.



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