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Preparation of these two materials, functional and preliminary application in biomedical research carried out, the paper is divided into the following areas: 1. TEOS and by regulating the amount of added NH3┬ĚH2O, controllably prepared with different particle size mesoporous silicon dioxide nanomaterials. Select three of granular product (80nm, 200nm and 320nm) for the study. First, the co-precipitation of a series of different silane (3-aminopropyl triethoxysilane, APTES) legal content, particle size of the mesoporous nanomaterials 80nm, and the plasmid DNA (pDNA) interaction study APTES amount of material for the adsorption and protect pDNA impact. The results show that: with the increase of APTES amount of material brought punctuality load gradually increased, the amount of adsorption pDNA by electrostatic interaction is gradually increasing, have good adsorption performance of all samples pDNA. The APTES particles containing an appropriate amount of in order to fully protect the pDNA. That APTES i.e. containing appropriate sample well can fully protect pDNA pDNA adsorption, this material has become possible gene vector. 2. In the work, based on a sample with a sample containing an appropriate amount of silane 4 (in which 7.5: 1 molar ratio refers to the TEOS / APTES's), pcDNA3.1 (+) and the other two plasmids - PKB-HA and PEGFPN3 role. Experimental results show that the samples 4 both good adsorption can fully protect pDNA pDNA, description of the synthesis of the product with the pDNA is broadly applicable. Preliminary experiments the samples were used as gene carriers PEGFPN3 gene transfection showed: Sample 4 can PEGFPN3 into cells, although the transfection efficiency is very low, indicating that the material may be used as gene vectors, optimized conditions related work in progress. 

3. Research containing different amount of silane, a particle size of 200nm and 320nm mesoporous material is subjected to adsorption and protection pcDNA3.1 (+). Consistent with Am-MSNs-80 results. However, the adsorption capacity of two kinds of sample size decreases, and the degree of protection pDNA was also weak trend. This indicates that the amount of APTES are the main factors affecting the adsorption material and protect pDNA, while medium size mesoporous materials for adsorption and protect pDNA also plays a role. 4. Synthesis of three dual-functionalized mesoporous silicon dioxide nano-materials surface modification method, respectively, of chitosan modified MSNs (CF-Am-MSNs), hydroxyapatite wrapped MSNs (F-Am- HA-MSNs) and polyethylene glycol-modified MSNs (PEG-F-Am-MSNs). And there are even fluorescent agent FITC, for cell labeling. Three materials on cell activity and the ability of the cell to swallow test results showed that: compared with the chitosan modified MSNs, lower hydroxyapatite wrapped MSNs and polyethylene glycol-modified MSNs cytotoxicity, with more good biocompatibility and ability to swallow in the higher cells. This indicates that functional groups of the modified mesoporous nanomaterials in biomedical applications have an important impact. 

5. Nano CaCO3 as a template for preparing hollow mesoporous silicon dioxide shell nanomaterials, given its enormous potential in terms of loading and transportation of drugs, our goal is to synthesize multi-dispersion, biocompatibility products with high efficiency to be absorbed by the cells, which is a prerequisite as a drug carrier. Experimental results show that we have synthesized a hollow shell mesoporous silicon dioxide nano-materials with good dispersion, high biocompatibility.



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