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During the manufacture of colloidal silicon dioxide, the vaporized silicon tetrachloride reacts with water (formed by a hydrogen oxygen flame) to form the primary particles of silicon dioxide. The particle size mentioned in the Pharm. Eur. monograph Silica Colloidal Anhydrous refers to the size of these primary particles. However, these particles do not remain isolated, but collide, and sinter together, resulting in branched chain aggregates.

The aggregates are the smallest actual units of colloidal silicon dioxide. Once the aggregates cool down to below the fusion point, additional collisions result in mechanical entanglement and bonding of the chains, called agglomeration. Because agglomerates are only bound through weak forces, they can easily be broken down to aggregates during mixing or dispersion.

To produce hydrophobic Pharma, hydrophilic colloidal silicon dioxide is treated with dimethyldichloro silane in a consecutive reaction step that follows immediately after the generation of silica particles as described above. In recent years, the colloidal crystals of common concern to chemists and physicists. Nano Crystal occupy each point or micron particle self-assembly behavior of atomic force microscopy and scanning electron microscopy can be clearly observed. Preparation of good monodisperse, smooth surface of silicon dioxide spherical particles, succinic acid chemically bonded to the surface of silicon dioxide colloidal spheres to improve its Zeta potential, then using vertical deposition was prepared in an aqueous solution of colloidal silicon dioxide.



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